BIOEQUIVALENCE BETWEEN INNOVATOR AND GENERIC TACROLIMUS IN LIVER AND KIDNEY TRANSPLANT RECIPIENTS: A RANDOMIZED, CROSSOVER CLINICAL TRIAL.

Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial.

BACKGROUND:Although the generic drug approval process has a long-term successful track record, concerns remain for approval of narrow therapeutic index generic immunosuppressants, such as tacrolimus, in transplant recipients.Several professional transplant societies and publications have generated skepticism of the generic approval process.Three ma

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Social adversity during juvenile age but not adulthood increases susceptibility to an immune challenge later in life

Adverse experiences in early life can increase mental vulnerability to immune challenges experienced later in life, which may induce the development of stress-related psychopathologies.Here, we investigated whether the combined effect of both events is higher if the first adverse experience occurs when the brain is still in development.Therefore, m

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